The examples aim at sharing used code to handle simulation-based
workflows with NMsim. When building your own code, please also see the
manuals of key functions, ?NMsim
being an obvious example.
NMsim - Seamless NONMEM Simulation
Platform in R is the place to start. It contains basic information
to get you started and demonstrates the most common types of
simulations.
You can let your interests guide your next topic. Use Requirements and Configuration as needed.
If you have not yet run your first successful NMsim()
calls, it’s worth a read, at least half-through.
For simulation with variability on parameters ($THETA’s,
$OMEGA’s, and $SIGMA’s), currently most up to
date is NMsim - Simulation-Based Forest
Plots with NMsim
Also, see recent Publications.
Philip Delff
- Configuration
- Simulation of typical subjects and new subjects
- Creation of Simulation data sets
- Simulate multiple models
- Reuse Emperical Bayes’ Estimates (known ETAs)
- Read previously generated simulations
Philip Delff
- Create Dosing Events
- Add Sampling Events
- Add Time After Previous Dose and Related Information
- Multiple Endpoints (e.g. parent and metabolite)
- Cohort-Dependent or Individual Sampling Schemes
Philip Delff
- Reuse Estimation Data for Simulation
- Plotting using
tidyvpc
- Use a different input data set: Change the ACCEPT/IGNORE
Statements
- Use a different input data set: Manually Subset Data
Philip Delff, Boris Grinshpun
- Generation of Simulation Input Data
- Define Covariates to Analyze
- Simulation With Parameter Uncertainty
- Post processing
- Plotting
- Comparison of Different Simulation Methods
- Post-Processing Step-By-Step
Philip Delff, Simone Cassani
- Control whether and how to update parameter values according to the
final model parameter estimates using the
inits
argument.
- Modify model parameter values (
$THETA,
$OMEGA and SIGMA) to specify values using the
inits argument
- Use the
modify argument to do custom manipulations of
any parts of the control stream before simulation.
- Modify data exclusions/inclusions (
$IGNORE/$ACCEPT)
using the filters argument.
- Adjust
$SIZES variables using the sizes
argument.
Philip Delff
- Specify the path to the Nonmem executable
(
path.nonmem).
- Set default values for
path.nonmem and output
directories.
Examples waiting for updates
