NMsim Examples

June 18, 2025 using NMsim 0.2.3.906

The examples aim at sharing used code to handle simulation-based workflows with NMsim. When building your own code, please also see the manuals of key functions, ?NMsim being an obvious example.

Guide
Simulation-Based Forest Plots with NMsim is the place to start. It contains basic information to get you started and demonstrates the most common types of simulations.

Secondly, you can let your interests guide your next topic. Use Requirements and Configuration as needed. If you have not yet run your first successful NMsim() calls, it’s worth a read, at least half-through.

For simulation with variability on parameters ($THETA’s, $OMEGA’s, and $SIGMA’s), currently most up to date is NMsim - Simulation-Based Forest Plots with NMsim

Also, see recent Publications.

Simulation-Based Forest Plots with NMsim

Philip Delff

• Configuration
  
• Simulation of typical subjects and new subjects
  
• Creation of Simulation data sets
  
• Simulate multiple models
  
• Reuse Emperical Bayes’ Estimates (known ETAs)
  
• Read previously generated simulations

Data Set Creation with NMsim

Philip Delff

Simulate Known Subjects Using Emperical Bayes Estimates (Etas)

Philip Delff

Simulation-Based Forest Plots with NMsim

Philip Delff, Boris Grinshpun

Simulation with Parameter Uncertainty

Philip Delff

Requirements and Configuration

• Specify the path to the Nonmem executable (path.nonmem).
• Set default values for path.nonmem and output directories. #### Philip Delff {.authors}

Examples waiting for updates

Simulation with Modifications to Parameters and Model Code

Simone Cassani, Philip Delff

VPC Simulations

Philip Delff

Simulation of residual variability

Philip Delff

Reuse simulated subjects

Philip Delff

NMsim and speed

Philip Delff